Mapping multiple QTL using linkage disequilibrium and linkage analysis information and multitrait data

Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis.

Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat...

Multitrait fine mapping of quantitative trait loci using combined linkage disequilibria and linkage analysis.

A novel multitrait fine-mapping method is presented. The method is implemented by a model that treats QTL effects as random variables. The covariance matrix of allelic effects is proportional to the IBD matrix, where each element is the probability that a pair of alleles is identical by descent, given marker information and QTL position. These probabilities are calculated on the basis of simila...

linkage disequilibrium and association mapping

Bolck Linkage Disequilibrium Mapping

1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...

Cross Validation of Qtl from Linkage Analysis and Linkage Disequilibrium Analysis

Although feed conversion efficiency is one of the key drivers of profitability in beef production, conventional methods of selecting for feed efficiency in beef cattle rely on a costly and time consuming collection of feed intake measurements. If genetic markers were available for this trait, they could greatly reduce the cost of selecting for more efficient cattle. Identification of markers or...